Achieving enhanced cell penetration of short conformationally constrained peptides through amphiphilicity tuning

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Chem. Sci., 2017, 8,7576-7581DOI: 10.1039/C7SC03614K, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Yuan Tian, Xiangze Zeng, Jingxu Li, Yanhong Jiang, Hui Zhao, Dongyuan Wang, Xuhui Huang, Zigang LiWe synthesized a panel of conformationally constrained peptides with either [small alpha]-helix or [small beta]-hairpin conformations. We tuned the amphiphilicity of these constrained peptides with different distributions of charged or hydrophobic residues and compared their cellular uptake efficiencies in different cell lines.The content of this RSS Feed (c) The Royal Society of Chemistry

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